inflammation · Mechanism Report
Do fumonisins cause oxidative stress and inflammatory signaling that promote chronic innate immune activation?
Fumonisin exposure can induce reactive oxygen species and inflammatory cytokine pathways that contribute to sustained innate immune activation.
This is what AI claimed
Fumonisins can induce oxidative stress and inflammatory immune signaling, contributing to chronic innate immune activation.
Executive summary
The claim states that fumonisins generate oxidative stress and trigger proinflammatory signaling, which together can maintain persistent activation of innate immune responses. The mechanism model frames this as toxin-driven ROS production and inflammasome/cytokine pathway activation that feed into chronic innate immune stimulation.
Verified conclusion
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References
- The effects of resveratrol on SIRT2, SIRT3 expression levels and oxidative DNA damage in fumonisin-induced hepatotoxicity in BALB/c mice — vetarhiv.vef.unizg.hr
- Fumonisin B1 Epigenetically Regulates PTEN Expression and Modulates DNA Damage Checkpoint Regulation in HepG2 Liver Cells — mdpi.com
- Research Progress on Fumonisin B1 Contamination and Toxicity: A Review — pmc.ncbi.nlm.nih.gov
- Dose and Exposure Time-Dependent Renal and Hepatic Effects of Intraperitoneally Administered Fumonisin B1 in Rats — pmc.ncbi.nlm.nih.gov
- The combined effect of Deoxynivalenol and Fumonisin B1 on small intestinal inflammation mediated by pyroptosis in vivo and in vitro. — linkinghub.elsevier.com
- mTOR-Mediated Autophagy Regulates Fumonisin B1-Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro. — pubs.acs.org
- Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines. — linkinghub.elsevier.com
- Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. — linkinghub.elsevier.com
- Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants — frontiersin.org
- Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling, and disease[S] — pmc.ncbi.nlm.nih.gov
- Cell death induced by mycotoxin fumonisin B1 is accompanied by oxidative stress and transcriptional modulation in Arabidopsis cell culture — pmc.ncbi.nlm.nih.gov
- Longan Polysaccharides with Covalent Selenylation Combat the Fumonisin B1-Induced Cell Toxicity and Barrier Disruption in Intestinal Epithelial (IEC-6) Cells — mdpi.com
- Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. — pmc.ncbi.nlm.nih.gov
- Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. — linkinghub.elsevier.com
- Targeted Sphingolipid Analysis in Heart, Gizzard, and Breast Muscle in Chickens Reveals Possible New Target Organs of Fumonisins — mdpi.com
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